Virzith | 200 mg/5 ml Powder For Suspension
Price: 20 ml bottle: ৳ 100.00 | 50 ml bottle: ৳ 180.00
COMPOSITION
Virzith powder for suspension: When reconstituted, each 5 ml suspension contains Azithromycin Dihydrate USP equivalent to Azithromycin 200 mg.
PHARMACOLOGY
Virzith (Azithromycin) is an azalide antibiotic, subclass of the macrolide class of antibiotics. Virzith (Azithromycin) acts by binding to the 50s ribosomal subunit of susceptible organisms and thus interferes with microbial protein synthesis. Virzith (Azithromycin) demonstrated activity in vitro, against a wide range of gram-positive and gram-negative bacteria including: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes (Group A) and other Streptococcal species; Haemophilus influenzae and parainfluenzae; Moraxella catarrhalis; anaerobes including Bacteroides fragilis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Haemophilus ducreyi, Neisseria gonorrhoeae and Chlamydia trachomatis. Azithromycin also demonstrates activity in vitro against Legionella pneumophila, Mycoplasma pneumoniae and hominis; Campylobacter sp., Toxoplasma gondii and Treponema pallidum.
INDICATIONS
Virzith (Azithromycin) is indicated for infections (caused by susceptible organisms) in lower respiratory tract infections including bronchitis and pneumonia, in upper respiratory tract infections including sinusitis and pharyngitis/tonsillitis, in otitis media, and in skin and soft tissue infections. In sexually transmitted diseases in men and women, Virzith (Azithromycin) is indicated in the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis.
DOSAGE & ADMINISTRATION
Virzith can be taken with or without food.
Adults: For lower respiratory tract infections including bronchitis and pneumonia , upper respiratory tract infections, including sinusitis and pharyngitis/ tonsillitis, otitis media and skin and soft tissue infections, the total dose of Virzith is 1.5 gm given as 500 mg once daily for 3 days. An alternative to this dosage schedule is that 500 mg once daily on day 1, followed by 250 mg once daily for next 4 days.
For sexually transmitted diseases caused by chlamydia trachomatis, the dose of Virzith is 1 gm given as a single dose. Alternatively, 500 mg once daily on day 1, followed by 250 mg once daily for next 2 days may also be given.
Use in the elderly: Normal adult dosage is recommended.
Children: The dose of Virzith in children over 6 months of age is 10mg/kg body weight once daily for 3 days. Alternatively, 10 mg/kg on day 1, followed by 5 mg/kg for next 4 days is also recommended. There is no information on use of Azithromycin on children under 6 months of age.
CONTRAINDICATIONS
Azithromycin is contraindicated in patients hypersensitive to Azithromycin or any other macrolide antibiotic. Co-administration of ergot derivatives and Azithromycin is contraindicated. Azithromycin is contraindicated in patients with hepatic diseases.
SIDE EFFECTS
Azithromycin is well tolerated with a low incidence of side effects. The side effects include nausea, vomiting, abdominal discomfort (pain/cramps), flatulence, diarrhoea, headache, dizziness, and skin rashes and are reversible upon discontinuation of therapy.
PREGNANCY & LACTATION
Pregnancy Category of Azithromycin is B. Animal reproduction studies have demonstrated that Azithromycin has no evidence of harm to the fetus. There are no adequate and well controlled studies in pregnant women. Since animal reproduction studies are not always predictive of human response, Azithromycin should be used during pregnancy only if adequate alternatives are not available. It is not known whether Azithromycin is secreted in breast milk. So, caution should be exercised when Azithromycin is administered to nursing women.
OVERDOSE EFFECTS
There is no data on overdosage with Azithromycin. Typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting and diarrhoea. Gastric lavage and general supportive measures are indicated.
PRECAUTIONS & WARNINGS
As with any antibiotic, observation for signs of superinfection with non-susceptible organisms, including fungi, is recommended. No dose adjustment is needed in patients with renal impairment.
STORAGE CONDITIONS
Keep in a dry place. Store below 30°C, away from light and moisture. Keep out of the reach of children.